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KMID : 1142220120070010007
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Regulatory Research on Food, Drug & Cosmetic
2012 Volume.7 No. 1 p.7 ~ p.12
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Studies on Analytical Methods of Chlorhexidine Gluconate by High Performance Liquid Chromatography
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Oh Mi-Hyun
Kim Sang-Seop
Kim Do-Jung
Kim Hyun-Ju
Shin Sun-Woo
Choi Myeong-Sin
Kim Dong-Sub
Choi Bo-Kyung
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Abstract
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Chlorhexidine gluconate is widely used for oral gargles, lens cleaners, feminie cleanser solutions, and antiseptics due to a strong antibacterial effect and low toxicity. The test method of chlorhexidine gluconate solution is listed in Korean Quasi-drug Codex(KQC), but it is difficult to apply to products with low concentration of chlorhexidine gluconate to be quantitatively analyzed. The purpose of this study is reviewing current analytical methods of chlorhexidine gluconate and establishing its internationally harmonized method. As a result, the test method of chlorhexidine gluconate would be reflected in the revision process of KQC and expected to provide the convenient method for quality control of quasi-drugs, cosmetics and drugs containing chlorhexidine gluconate.
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KEYWORD
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Quasi-Drug, Test Methods, Quality Control, Chlorhexidine gluconate, HPLC
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FullTexts / Linksout information
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Listed journal information
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